Article with EXTENSIVE info on Nitric Oxide is below this top vid with Dave Asprey 🛑
I Tried the $2 Secret “Age-Reversal” Pill (Nitric Oxide folks)
Core Health Benefits: From Blood Pressure to Immunity
A few years back when I was still unhealthy and overweight, I went to my dentist, and they took my blood pressure. It was very high at 139/89 and the dentist told me that often people have higher levels when visiting his office, but I should check with my doctor in case I really did have Hypertension Stage 1. Well, I had just fired my doctor for wanting to give me a Covid vaccine. She was not up on the latest on most topics, like most doctors, but the high blood pressure still bothered me. I bought a blood pressure cuff and did my research. Fat folks as I was often hampered with high blood pressure. So many things go wrong when you are overweight, and I seemed to suffer from most of it. Well…this started my journey down the NO research cave. Long story short – My pressure is now 118/80 at last take, and I was able to stop all problems using NO supplementation until I was able to get into shape. I was scared to death of getting a heart attack, and this, coupled with a change of diet, puts you into the best health situation you can be.
At its core, NO relaxes blood vessels, improving endothelial function and promoting vasodilation—the widening of arteries for better blood flow. This directly tackles high blood pressure, a silent killer affecting one in three adults. Supplements like L-citrulline outperform L-arginine in sustaining NO levels, reducing systolic pressure by up to 5-10 mmHg in clinical trials. For heart health, NO enhances oxygen delivery, cuts inflammation, and prevents plaque buildup, slashing risks of heart disease and stroke. It’s no wonder NO boosters are hailed for managing type 2 diabetes, where improved insulin sensitivity and glucose uptake help stabilize blood sugar.
Immunity gets a major lift too. NO amps up antimicrobial defenses, fortifying white blood cells to combat pathogens. It regulates inflammation, preventing overreactions that lead to chronic conditions. During infections, NO production spikes to kill bacteria and viruses, explaining why nitrate-rich diets correlate with fewer colds and better recovery. For athletes, NO reduces muscle soreness by 20-40% post-workout, accelerates healing via growth factor upregulation, and boosts endurance by optimizing oxygen use. Erectile dysfunction sufferers see gains, as NO facilitates smooth muscle relaxation for better erections—rivaling pharma options without side effects. Even brain health benefits: NO supports neuroplasticity, enhancing learning and memory while protecting against neurodegenerative decline.
Latest Research: 2025 Breakthroughs in NO Science
Here is the NO Product I took daily when I was still grossly overweight out of fear of a heart attack. Today I take it maybe 3 times a week.
Photobiology studies from 2024 (echoed in 2025 reviews) showed UVB exposure ramps NO for 45% faster wound healing, linking sun therapy to skin and systemic health. Immunity research advanced too. Examine.com’s October update confirmed NO’s signaling in vascular relaxation aids immune modulation, with supplements cutting infection risks via better oxygenation.
Biohacking Pundits Weigh In: Dave Asprey and Beyond
Dave Asprey, the “Father of Biohacking,” frequently touts NO for targeted performance hacks, but with caveats. In a July 2025 thread, he warned against “blindly boosting” NO, likening it to dumping NOS in a car engine without tuning—risking mitochondrial damage and accelerated aging. Asprey recommends short bursts: Pre-workout for pumps, hypoxia training, brain perfusion, or libido support. He stacks NO with antioxidants like glutathione, methylene blue, CoQ10, and molecular hydrogen to prevent oxidation. Nose breathing is his go-to hack, repeated across 2025 posts: It spikes NO, bolsters immunity, reduces allergies, and supports facial structure—while mouth breathing invites cavities and poor posture. In a July podcast with Dr. Nathan Bryan (DrNitric), Asprey delved into NO’s control over blood flow, mitochondria, neuroplasticity, insulin, and libido—calling it an “overlooked molecule.”
Andrew Huberman echoes the nose-breathing mantra, linking it to NO for better oxygenation and calm focus, though he hasn’t posted directly in recent searches. Ben Greenfield, in biohacking circles, praises NO for recovery, often stacking it with beets or L-citrulline for endurance—aligning with Asprey’s precision approach. These pundits agree: Supplement smartly—NO strips for quick hits, clean beets or citrulline for sustained levels—but test genes like NOS3 for personalization.
Harness NO for Peak Health
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